Our adaptive immune systems is highly efficient in protecting us from the most diverse intruders. B cells are an essential part of the adaptive immune system. Each B cell uniquely rearranges its genome several times to produce an unique antibody. Until very recently, the analysis of B cell populations circulating in the periphery at any given time was labor intensive and low throughput. Our lab focuses on developing and improving DNA sequencing tools to analyze B cells on a population and single cell level.
By analyzing B cells this way we aim to:
1) define the current state of the adaptive immune system and
2) identify and produce interesting antibodies.
I don’t think B cells have told us their whole story yet!